Till the end of 2016, our department has treated 78 patients of multiple system atrophy, with 49 male patients and 19 female patients, including 10 hereditary cases, and the age of patients is between 28-66 years old. The treatment effect is closely related to the type of disease, treating time of the disease and patient's specific disease progress. When treating, the treating effect of early to mid stage patient (before the disease damages language and deglutition function) is better than that of patients in the later stage; patient who progress slower will achieve better treatment effect.
Most patients can feel the improvement when they are still in the hospital, and the improvement can be seen from
1) reduction of muscular tensions
2)improvement of abnormal walking posture and deglutition
3) less bucking and mistaken swallowing
4) improvement of vagueness in speech
The treatment can stop disease progression, extend patient's life and improve the living quality in a certain period of time, but some patients in the later stage have little effect. The follow-up data confirms that patient’s condition is keep improving after treatment, for example, some patients can complete more fine motor tasks than before, such as writing and using the chopsticks, speaking clearly and loudly, having better appetite and improvement in postural hypotension. But we have to remind ourselves that all the transplantation of neurological stem cells can not cure multiple system atrophy, it can only improve patient's condition and slow down or even stop disease progress. If the disease keeps progressing, patients can receive transplantation for the second or third time to extend life and improve living quality.
The multiple system atrophy mainly affected the striatonigral system, olivopontocerebellar system and automatic nervous system, and the diseased area is mainly in the cerebrum and cerebellum. If we inject neural stem cells directly into the brain, we can get better effect to the condition. Our department is using the new neural stem cell transplantation based on transplantation via lumbar puncture in subarachnoid space since September, 2006. This new method is about locating the diseased region by the head MRI scan, and using stereotactic techniques to implant the stem cells via stereotactic brain surgery. The effect of this method is apparently impressive.