Ali is a Sudan 58 years old male patient suffering from motor neuron disease. He felt his hands weakness when he was climbing the ladder without obvious incentive, no accompanying symptoms such as headache, dizziness in December, 2008, while he had not paid attention to it. The weakness of his muscles aggravated, he felt the weakness of his right lower limb, hard to walk, with involuntary proximal muscle contraction, then affected the left lower limb, accompanying with muscle atrophy in September, 2010. He consulted the doctors in his local hospital and received MRI of head, which indicated: 1. No abnormal inside his head; 2. Acute maxillary sinusitis. He was treated nerve nutrition and anti-inflammation medication in the local hospital. The weakness of his limb muscles aggravated further, he consulted the local hospital to be diagnosed as motor neuron disease, then was offered nerve nutrition etc. treatments, the weakness of his limbs did not aggravate further as a result. He consulted to PLA navy neural institute, then was admitted to our hospital for the chief complaint of progressive weakness of limbs muscles with muscle atrophy for over 2 years. According to his medical history and physical signs and symptoms, he was diagnosed as motor neuron disease.
He received a round stem cell treatment including a stem cell transplantation via stereotactic brain surgery and 2 stem cell injections via lumbar puncture.
Before the stem cell treatment:
- The muscle strength of his limbs was weak, he could not move his 4 limbs;
- The muscle volume of his lower limbs was atrophy slightly.
After the stem cell treatment:
- The muscle strength of his limbs is improved, he can shrug his shoulders;
- The muscle volume of his lower limbs is improved;
- The body sensation, for example, the pain or temperature feeling, is normal;
- His medical condition is stable without aggravating.