——MD of Neurosurgery, Harbin Medical University, China
——Chief Physician and Assistant Researcher of Functional Neurosurgery Department of General Hospital of Chinese People’s Armed Police Forces
——Contributing editor of Chinese Journal of Clinicians
——Visiting professor of Heilongjiang University of Chinese Medicine
Chief physician, assistant researcher.
Pioneer Chinese expert doctor to take outbound stem cell treatment for foreign patients.
More than 17 years’ medical experience; more than 13 years’ clinical experience of stem cell therapy. Participated in thousands of stem cell transplantation cases, including: more than 500 interventional treatment, around 1000 CT-guided operation, more than 2000 brain surgery.
Good at the diagnosis, treatment and post-treatment rehabilitation technology of cerebral palsy, brain injury, spinal cord injury, cerebral hemorrhage, cerebral thrombosis sequelae. Participated in the first CT guided stereotactic brain stem cell transplantation, interventional treatment of spinal cord injury, diabetes, cirrhosis of the liver. At present he is mainly responsible for stem cell transplantation related work, including surgical plan formulation, the specific operation, postoperative clinical observation, new transplantation methods development.
2006,2012,Excellent Doctor of General Hospital of Chinese People’s Armed Police Forces;
2009,Class three collective commendation of General Hospital of Chinese People’s Armed Police Forces;
2009,Collective commendation of 8th Bethune Award in General Hospital of Chinese People’s Armed Police Forces;
2010,Medical productive award of Beijing Chinese People’s Armed Police Forces;
2011,Award for scientific and technological advancement of General Hospital of Chinese People’s Armed Police Forces;
1．Wang X, Hu H, Hua R, Yang J, Zheng P, Niu X, Cheng H, Dai G, Liu X, Zhang Z, An Y. Effect of umbilical cord mesenchymal stromal cells on motor functions of identical twins with cerebral palsy: pilot study on the correlation of efficacy and hereditary factors. Cytotherapy. 2015,17(2):224-31. (IF: 3.10) 2．Liu X, Zheng P, Wang X, Dai G, Cheng H, Zhang Z, Hua R, Niu X, Shi J, An Y. A preliminary evaluation of efficacy and safety of Wharton's jelly mesenchymal stem cell transplantation in patients with type 2 diabetes mellitus. Stem Cell Res Ther. 2014,5(2):57. (IF: 4.63) 3. Hongbin Cheng, Xuebin Liu, Rongrong Hua, Guanghui Dai, Xiaodong Wang, Jianhua Gao and Yihua An.Clinical observation of umbilical cord mesenchymal stem cell transplantation in treatment for sequelae of thoracolumbar spinal cord injury. Journal of Translational Medicine , 2014 , 12 (1) :1-8 . （IF 3.649） 4． Sen Wang, Hongbin Cheng, Guanghui Dai, Xiaodong Wang,Rongrong Hua, Xuebin Liu, Peishen Wang, Guangming Chen,Wu Yue, Yihua An. Umbilical cord mesenchymal stem celltransplantation significantly improves neurological function in patients with sequelae of traumatic brain injury.Brain Research 2013.08.(1):76-84.（IF 2.879）. 5． Hong-Bin Cheng.Wu Yue.Chen Xie.Ru-You Zhang.Shao-Shan Hu.Zhi Wang. IDH1 mutation is associated with improved overall survival in patients withglioblastoma:a meta-analysis. Tumor Biology.2013;8(1): 4083-4087.（IF 2.14）. 6. Hong-Bin Cheng,Chen Xie,Ru-You Zhang,Shao-Shan Hu,Zhi Wang,Wu Yue*. Xeroderma Pigmentosum Complementation Group F Polymorphisms Influence Risk of Glioma. Asian Pacific Journal of Cancer Prevention. 2013;14 (7):4083-4087. （IF 1.24）. 7. XiaoDong Wang, HongBin Cheng, RongRong Hua, Jing Yang, GuangHui Dai, Zan Zhang, RenZhi Wang, Chuan Qin & YiHua An. Effects of bone marrow mesenchymal stromal cells on gross motorfunction measure scores of children with cerebral palsy: a preliminary clinical study. Cytotherapy. 2013;15 :1549-1562. （IF 3.05；）. 8. Dai G, Liu X, Zhang Z, Wang X, Li M, Cheng H, Hua R, Shi J, Wang R, Qin C, Gao J, An Y. Comparative analysis of curative effect of CT-guided stem cell transplantation and open surgical transplantation for sequelae of spinal cord injury. J Transl Med. 2013,11:315.(IF: 3.46) 9. R Hua, J Shi, X Wang, J Yang, P Zheng, H Cheng, M Li, G Dai and Y An. Analysis of the causes and types of traumatic spinal cord injury based on 561 cases in China from 2001 to 2010. Spinal cord. 2013, 51:218–21. (IF：1.90) 10. Li, Min; Yu, Aixue; Zhang, Fangfang; Dai, GuangHui; Cheng, Hongbin; Wang, Xiaodong; *An, Yihua Treatment of one case of cerebral palsy combined with posterior visual pathway injury using autologous bone marrow mesenchymal stem cells JOURNAL OF TRANSLATIONAL MEDICINE, 10, 2012/5/18. 11. Sun, Chongran, Zhang, Han, Li, Jin, Huang, Hua, Cheng, Hongbin, Wang, Yajie, Li, Ping, *An, Yihua.Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke Journal of Translational Medicine, 8, 2010/8/20. 12. Hu, Shao-Shan, Cheng, Hong-Bin, Zheng, Yong-Ri, Zhang, Ru-You, Yue, Wu, Zhang, Han.Effects of photodynamic therapy on the ultrastructure of glioma cells.BIOMEDICAL AND ENVIRONMENTAL SCIENCES, 20(4), pp 269-273, 2007/8. 13. Wang Sen, Cheng Hongbin, Wang Xiaodong, Dai Guanghui, Hua Rongrong, Liu Xuebin,YiLong, Li Lusheng, *An, Yihua. Clinical effects analysis on umbilical cord mesenchymal stem cell transplantation for 35 cases of traumatic brain injury. The newspaper of Harbin Medical University, 2013;01:78-81. 14. Liu Yansong, Wang Xiaodong, Yang Jing, Hua Rongrong, Cheng Hongbin, Liu Yafei, * AnYihua. Evaluation of autologous bone marrow mesenchymal stem cells transplantation on motor functions of cerebral palsy. Chinese Journal of Tissue Engineering Research(23), pp 4290-4295， 2012. 15. Cheng Hongbin, Yi Long, Ma Zhanbin, Wang Xiaodong, Dai Guanghui, Li Min, Liu Xuebin,Gao Jianhua, *An Yihua. Evaluation on clinical effects of urodynamics test for urination disorder of spinal cord injury after stem cell transplantation. JOURNAL OF NEUROSCIENCE AND MENTAL HEALTH. 2011,11（6）：563-565 16. Ma Zhanbin, Cheng Hongbin, Dai Guanghui, Zhang Zan, Mu Xuetao, Liu Xuebin, *An Yihua. The clinical application value of magnetic resonance imaging in the display of stem cell transplantation targets of stereotactic brain surgery. Chinese Journal of Clinicians(electronic edition). 2011,5 ( 23 ):7082-7084 17. Jia Lina, Song You, Cheng Hongbin. Effects of ischemic postconditioning on SOD and MDA in rats with focal cerebral ischemia reperfusion. Aerospace Medicine. 2011，22（9）：1049-1051 18. Wang Chengjun, Zhang Han, Li Lusheng, Cheng Hongbin, *An Yihua. Biological property, differentiation and application study of human umbilical cord mesenchymal stem cells. Medical Journal of the Chinese People’s Armed Police Forces. 2010,21（4）：349-351 19. Li Lusheng, Zhang Han, Wang Chengjun, Cheng Hongbin, *An Yihua. Separation and Biological Property of Bone Marrow Mesenchymal Stem Cells. Journal of Clinical Rehabilitative Tissue Engineering Research. 2010,14（10）：1869-1873 20. Cheng Hongbin, Liu Xuebin, Yi Long, Zhang Zan, Dai Guanghui, Li Min, Gao Jianhua, *An Yihua. Clinical effects analysis on 60 cases of spinal cord injury sequelae by CT-guided bone marrow mesenchymal stem cells transplantation. JOURNAL OF NEUROSCIENCE AND MENTAL HEALTH 2010,10（2）：160-161 21. Cheng Hongbin, Yi Long, Liu Xuebin, Dai Guanghui, Zhang Zan, Ma Zhanbin, Wang Xiaodong, Li Min, *An Yihua. Effect analysis on mesenchymal cell transplantation for 80 cases of cerebral palsy by stereotactic brain surgery. JOURNAL OF NEUROSCIENCE AND MENTAL HEALTH. 2010，10（4）：355-357 22. Wang Xiaodong, Yang Jing, Li Min, Hua Rongrong, Zheng Pei, Zhang Qian, Zhang Fangfang, Cheng Hongbin, Yi Long, Yu Aixue, *An Yihua. Effects of bone marrow mesenchymal stem cells on gross motorfunction of children with cerebral palsy. Journal of China-Japan Friendship Hospital. 2010,24（6）：337-342 23. Wang Xiaodong, Yang Jing, Zhang Qian, Zheng Pei, Li Min, Cheng Hongbin, Dai Guanghui,Zhang Zan, Zhang Fangfang, Yi Long, *An Yihua. Effects of oligodendrocyte precursor cells transplantation on inflammatory response of neonates hypoxic ischemic encephalopathy. Acta Laboratorium Animalis Scientia Sinica. 2010,18（6）：535 - 537 24. Zhang Xiaoming, Cheng Hongbin, Li Haibo. Effect analysis on periodic comprehensive therapy on rehabilitation of severe craniocerebral injury. Chongqing Medicine. 2009, 02: 25. Hu Shaoshan, Gu Shuqing, Zhang Xiaoming, Cheng Hongbin. Histopathological changes of rabbit brain after 830 nm semiconductor laser irradiation. Chinese Journal of Laser Medicine & Surgery. 2008, 2: 26. Song You, Cheng Hongbin, Lu Xiaohong. Effects of HIF-1α, HSP70 expression and GM1 to the changes in rat brain hemorrhage area. Chinese Journal of Modern Drug Application. 2008,16: 27. Cheng Hongbin, Hu Shaoshan, Zheng Yongri, Li Min, *An Yihua. Clinical effect analysis of neural stem cell transplantation for 20 cases of traumatic intracranial hematoma sequela. Chinese Journal of Rehabilitation Theory and Practice. 2007，13(5):454-455 28. Zhang Ruyou, Zheng Yongri, Hu Shaoshan, Cheng Hongbin, *An Yihua. Clinical effect analysis of neural stem cell transplantation in the treatment of 50 cases of stroke sequelae. Chinese Journal of Clinical Rehabilitation. 2006, 10(9): 138-139. 29. An Yihua, Cheng Hongbin, Zhang Ruyou, Zhang Zan, Li Jizhong. Clinical application and prospect of neural stem cells. Journal of Internal Intensive Medicine. 2005, 11(5): 238-239.
CCTV Special Reports:
Memo: CCTV—China Central Television (the largest national television of China)
1.Nov.11, 2013: CCTV-10“Approaching Science”program broadcasted “The magic cells”—reported the story of a Cerebral Palsy patient-Lulu’s stem cell transplantation (the stem cell treatment operated by Dr.An Yihua’s team). (Program Link)
2.Nov. 8th, 2013: CCTV-1 annual award ceremony of“Most Filial youngsters of 2013, China”. One of the filial youngsters—A girl named Huang Feng was promoted as the Top 1 among the all the youngsters. Dr. An Yihua’s team had helped her to treat her father, a peasant injured when take labor work(Spinal cord injury). They don’t have money for treatment, Dr. An provided the treatment for him for free. The treatment is quite successful. During the award ceremony, Dr. An was invited by CCTV as a VIP guest to give the prize to Huangfeng.(Program Link)
3.June 11th, 2010: CCTV-12 “Morality Observation”program broadcasted“Daddy’s little mom”，Reported the news of Dr.An’s team helped the peasant worker Mr. Huang Zhiren for free. And the treatment is quite successful.(Program Link)
4.April, 30th , 2010，CCTV-10“Approaching Science”broadcasted “Miracle of Half brain”，Reported a serious Traumatic Brain Injury patient, Mr. Zhanglei, Army soldier, who only have Half Brain left after the incident. Dr.An’s team took stem cell transplantation for him and Zhanglei improved quite successful. How successful? Zhanglei can walk and back his work position and already get married. (Program Link)
5.April 22nd and April 25th, 2009: CCTV-10 “Approaching Science” broadcasted“Disaster of Broken Neck”,“Rebirth of Broken Neck”,Reported the moving story of Our dept. (Dr. An’s team) treated a Army soldier—Mr. Dongchuan, who was injured with Cervical Spine Cervical cord(C3-C7). It’s a very severe injury. That time, most doctors don’t think Dongchuan may even wake up. Could die any moment or could be a vegetable all the life. Can you believe it? Now he can walk with a walker and can eat by himself. (Program Link)
6.April 28th ,2010: CCTV-10“All Science Discovering”program broadcasted“Revived Body”，reported our Dept.’s scientific theories of stem cells to treat spinal cord injury patients and successful SCI cases. (Program Link)
7.Jan 28th, 2010: CCTV-1“Population”Program broadcasted“Motherhood support the sky of Cerebral Palsy sisters”，Reported our Dept.(Dr. An’s team) treated twin cerebral palsy sisters in great success with stem cell transplantation.(Program Link)
8.Jun. 23rd, 2008: CCTV-10“Science and Technology Review” Program broadcasted“Twin’s Dream”,reported the scientific theories of stem cell to treat cerebral palsy and the successful case on twins sisters.(Program Link)
9.Dec. 17th 2011: CCTV“Record of Actual Events”Program“ Warm life of a Motor Neuron Disease Patient -Wangjia”，Reported our case to use Stem cells treated Montor neuron disease sucessfully. Wangjia is also a representative of China national MND Patients.(Program Link)
10.Nov. 5th to Nov.6th 2010: CCTV-12“Morality Observation”Program broadcasted“Never give up”（Series），reported the touching story of our Dept. treated cerebral palsy twins successfully. (Twins sisters name: Xinwen & Xinyue). (Program Link 1 ) (Program Link 2 )
11.June, 2011: CCTV-3“Avenue of Stars(星光大道)”Program，Famous compere—Mr.Bi Fujian invited Dr. An Yihua and related national government officers to join the program again. Bi Fujian announced to assist our Dept. to treat more Cerebral palsy patients of poor families, A Fund named “Kids Star Fund”was founded. (Program Link)
12.Dec. 2nd , 2010: CCTV-3“Avenue of Stars(星光大道)”Program，Famous compere—Mr.Bi Fujian invited Dr. An Yihua and our dept. members to site. Reported the touching stories of our treatments for cerebral palsy kids free of charge; this program also call on whole the society to care cerebral palsy patients and their families.(Program Link)
1.8th Oct. 2005, Chinese Journal of Critical Patients, Clinical practice of Stem cell transplantation, Yichang China. 2.19th Jan. 2006, Laser Medicine Annual Meeting, Clinical practice of Stem cell transplantation, Harbin China. 3.5th June 2006, Heilongjiang University of Chinese Medicine, Research Progress of Stem Cells, Harbin China. 4.15th Feb. 2007, Laser Medicine Annual Meeting, Stem Cell Therapy for CNS Diseases, Harbin China. 5.9th Aug. 2007, Shangdong Biotherapy Annual Meeting,Stem Cell Therapy for CNS Diseases, Shangdong China. 6.5th March 2008, Chinese Journal of Minimally Invasive Neurosurgery, Stem Cell Therapy for Stroke, Anhui China. 7.21st Sept. 2009, Chinese Journal of Neurosurgery, Stem Cell Therapy for Traumatic Brian Injury, Huangshan China. 8.16th July 2010, Chinese Journal of Neurosurgery, Stem Cell Therapy for CNS Diseases,Beijing China. 9.19th April 2011, Xinjiang General Hospital of Chinese People’s Armed Police Forces, Stem Cell Therapy for CNS Diseases, Xinjiang China. 10.15th June 2012, Laser Medicine Annual Meeting, Research Progress of Stem Cells, Harbin China. 11.2nd March 2008, Chinese Journal of Minimally Invasive Neurosurgery, Stem Cell Therapy for Parkinson’s Disease, Anhui China. 12.June~December 2016, 80 courses given to Help Foundation of Chinese Women and Children’s Development Foundation, Prevention and Treatment for Stroke, Beijing China.
1. Development of stem cell technology and products for treating Cerebrovascular Disease Sequelae. National 863 Stem Cell and Tissue Engineering project (2006AA02A115).
2. Experimental research on neural stem cell transplantation to treat Temporal Lobe Epilepsy. Nature Science Foundation of China (30240052).
3. Experimentation and clinical research on traumatic brain injury and treatment with mild hypothermia. The 9th, Five-Year Key Project of Heilongjiang Province（G98L19-13).
FUNDED RESEARCH PROJECTS:
1. Neural stem cell transplantation to repair dysfunction after Cerebral Infarction in monkeys. The 10th Huo Yingdong Education Foundation Fellowship for Young Teachers of Higher Education (101043) 2. Research on the underlying mechanism of neural stem cell transplantation to treat Motor Neuron Disease. The New-Century Notable Talent Culture Plan of the Chinese Ministry of Education 3. Combination of neural stem cells and tissue engineering to treat post Cerebral Haemorrhage neurological dysfunction in monkeys. Nature Science Foundation of China (30371452) 4. Combination of neural stem cells and tissue engineering to repair facial nerve injury. Nature Science Foundation of Beijing City (30371452) 5. Combination of neural stem cells and tissue engineering to treat post Cerebral Haemorrhage Neurological Dysfunction. Beijing New Star of Science and Technology Culture Plan (H020821360130) 6. Combination of neural stem cells and tissue engineering to treat post Cerebral Haemorrhage Neurological Dysfunction in monkeys. International science and technology cooperation project of Beijing in 2003（2003012) 7. Neural stem cell transplantation to repair post Cerebral Haemorrhage dysfunction in rats. Beijing Notable Talent Culture Project 8. Preclinical research on neural stem cell transplantation to treat Stroke Sequelae. China Postdoctoral Foundation 9. Culture and transplantation of human multipotent neural stem cells: a pilot study. Beijing Young Research Culture Foundation 10. Preclinical and clinical study on the relationship between free radicals and delayed secondary brain injury after hypothermia protection. Research Foundation for Young Scientists (Heilongjiang Province) (Q99-19)